What can be a long-term effect of substance abuse?

The correct choice highlights that long-term substance abuse can lead to an increased risk of psychological disorders. Substance abuse often alters brain chemistry, which can result in various mental health challenges such as anxiety, depression, and other mood disorders. These issues may develop due to prolonged exposure to harmful substances or the way substances interact with mental health conditions.

In contrast, other choices suggest positive outcomes that are typically not associated with substance abuse. For example, improved academic performance and enhanced physical performance are more likely to be associated with healthy behaviors and choices. Similarly, better social relationships usually stem from positive interactions and lifestyle choices, which substance abuse can severely disrupt. Thus, the long-term effects of substance abuse are predominantly negative, underscoring the importance of understanding its implications on mental health.